Update on primary sclerosing cholangitis genetics
Henriksen, Eva K.K.; Melum, Espen; Karlsen, Tom H.
Abstract
Purpose of review: The pathogenesis of primary sclerosing cholangitis (PSC) involves heritable factors. This review summarizes the recent genetic studies and discusses the implications of identified risk loci.
Recent findings: A total of 16 PSC susceptibility loci have been identified in genome-wide association studies and related study designs. At least 33 additional loci are involved in what is increasingly acknowledged to represent a general pool of genetic risk loci for immune-mediated diseases. One important group of genes is part of well characterized immune pathways (e.g. interleukin 2 signaling), whereas for other loci the relationship to PSC pathophysiology is less evident . . . To read further, please click on the title.
(C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
Henriksen, Eva K.K.; Melum, Espen; Karlsen, Tom H.
Abstract
Purpose of review: The pathogenesis of primary sclerosing cholangitis (PSC) involves heritable factors. This review summarizes the recent genetic studies and discusses the implications of identified risk loci.
Recent findings: A total of 16 PSC susceptibility loci have been identified in genome-wide association studies and related study designs. At least 33 additional loci are involved in what is increasingly acknowledged to represent a general pool of genetic risk loci for immune-mediated diseases. One important group of genes is part of well characterized immune pathways (e.g. interleukin 2 signaling), whereas for other loci the relationship to PSC pathophysiology is less evident . . . To read further, please click on the title.
(C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
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