Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis
C. Rupp, K. Friedrich, T. Folseraas, A. Wannhoff, K. A. Bode, K.-H. Weiss, P. Schirmacher, P. Sauer, W. Stremmel, D. N. Gotthardt., Alimentary Pharmacology & Therapeutics Volume 39, Issue 8, pages 873–882, April 2014
Abstract
Background: A recent genome-wide association study identified the FUT2 secretor status and genotype defined by the single-nucleotide polymorphism rs601338 as potential genetic risk factor in primary sclerosing cholangitis (PSC), which significantly influences biliary bacterial composition.
Aim: To determine the impact of the rs601338-FUT2 genotype on frequency of biliary infections, development of dominant stenosis and liver-transplantation-free survival in patients with PSC.
Methods: Cohort study of 215 patients with PSC treated at our tertiary care centre with respect to their rs601338-FUT2 genotype. Results of endoscopic retrograde cholangiography and bile culture were analysed . . . To read further, please click on the title.
C. Rupp, K. Friedrich, T. Folseraas, A. Wannhoff, K. A. Bode, K.-H. Weiss, P. Schirmacher, P. Sauer, W. Stremmel, D. N. Gotthardt., Alimentary Pharmacology & Therapeutics Volume 39, Issue 8, pages 873–882, April 2014
Abstract
Background: A recent genome-wide association study identified the FUT2 secretor status and genotype defined by the single-nucleotide polymorphism rs601338 as potential genetic risk factor in primary sclerosing cholangitis (PSC), which significantly influences biliary bacterial composition.
Aim: To determine the impact of the rs601338-FUT2 genotype on frequency of biliary infections, development of dominant stenosis and liver-transplantation-free survival in patients with PSC.
Methods: Cohort study of 215 patients with PSC treated at our tertiary care centre with respect to their rs601338-FUT2 genotype. Results of endoscopic retrograde cholangiography and bile culture were analysed . . . To read further, please click on the title.
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