Scientific Research
This page is in a'blog' format with the latest scientific PSC research identified by Google Scholar, Readbyqmx.com and other sources added regularly.

​Primary sclerosing cholangitis (PSC) is a chronic and progressive cholestatic liver disease that often leads to the development of cirrhosis. Complications of PSC include pruritus, fatigue, vitamin deficiencies, metabolic bone disease, dominant biliary strictures, gallstones, and hepatobiliary malignancies, most commonly cholangiocarcinoma (CCA). Despite the presumed autoimmune etiology of PSC, a clear benefit from immunosuppressive agents has not yet been established, and their use is limited by their side effects. Endoscopy is required in evaluation of biliary strictures in PSC to rule out the possibility of CCA ... The full text of this article is available by clicking here. 
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Mohammed Saadi, Christine Yu, and  Mohamed O. Othman
J Clin Transl Hepatol. 2014 Mar; 2(1): 45–52. 
Published online 2014 Mar 15. doi:  10.14218/JCTH.2013.00021

Endoscopic management of primary sclerosing cholangiti

Ryan Law D.O. and Todd H. Baron M.D., Clinical Liver Disease: Special Issue: Autoimmune Liver Disease, Part 4, Volume 3, Issue 4, pages 79–82, April 2014

Abstract

Primary sclerosing cholangitis (PSC) is a progressive, chronic fibroinflammatory disorder involving the intra- and extrahepatic biliary tree that can lead to cirrhosis and liver failure in a subset of patients. Additionally, progression of PSC can lead to life-threatening episodes of ascending cholangitis and the development of cholangiocarcinoma (CCA). Herein we describe the endoscopic evaluation and therapeutic management of PSC and CCA . . . Please click here to read the full article