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Scientific Research
This page is in a'blog' format with the latest scientific PSC research identified by Google Scholar, Readbyqmx.com and other sources added regularly.

August 11th, 2015

8/11/2015

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Primary sclerosing cholangitis during childhood and adolescence

7/9/2014

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Primary sclerosing cholangitis during childhood and adolescence

Tamir Miloh and Pinar Bulut, Clinical Liver Disease Special Issue: Liver Disease in Children
Volume 2, Issue 5, pages 215–218, October 2013

Primary sclerosing cholangitis (PSC) is an idiopathic, chronic hepatobiliary disorder characterized by inflammation with progressive obliterative fibrosis and focal dilatation of the intrahepatic and/or extrahepatic bile ducts which leads to biliary cirrhosis and end-stage liver disease.[1] The clinical features of PSC in children and adolescents are summarized in Table 2. PSC is more common in Caucasian male patients and has a strong association with inflammatory bowel disease (IBD), especially ulcerative colitis. In children, secondary causes of sclerosing cholangitis include Langerhans cell histiocytosis, immunodeficiencies, and cystic fibrosis. The incidence of PSC in children is 0.23 cases per 100,000 person-years compared with 1.11/100,000 in adults.[2] . . . Please click here to access the full text of this article. There is also a video presentation and an interview with the authors

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Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

7/8/2014

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Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin


Yinka K. Davies, Cynthia J. Tsay, Dario V. Caccamo, Kathleen M. Cox, Ricardo O. Castillo, and Kenneth L. Cox
Case Reports in Transplantation
Volume 2013 (2013), Article ID 314292, 5 pages
http://dx.doi.org/10.1155/2013/314292

Abstract

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin ... Please click here to access to the full text of this article
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Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis

6/22/2014

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Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis 

James H. Tabibian, Felicity Enders, Mohamad H. Imam, Gururaj Kolar,  Keith D. Lindor, Jayant A. Talwalkar.
Annals of Hepatology,  2014, May-June, Vol. 13 No. 3, 2014: 384-389

Abstract

Introduction: Primary sclerosing cholangitis (PSC) is an idiopathic hepatobiliary disorder associated with an increased risk for cholangiocarcinoma (CCA) and a median survival time of 12 years. Reliable predictors of CCA and other major adverse events in PSC are currently lacking. Recently, serum IgE was found to be as- sociated with CCA in a Japanese cohort of PSC patients. Our aim in this study was to determine whether IgE levels predict time to CCA, liver transplantation, or death in a Western (USA-based) cohort of PSC pa- tints. 

Material and methods: Thirty-eight patients with PSC and IgE levels were identified and categorized into low or high IgE groups based on the sample median. Groups were compared with respect to clinical characteristics and adverse endpoint-free survival . . . Please click here to be taken to the full text article

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Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children and Adolescents

6/22/2014

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Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children and Adolescents.

Claudia Patricia Rojas, Rajasekhar Bodicharla,  German Campuzano-Zuluaga, Lina Hernandez, and Maria Matilde Rodriguez Posted online on April 22, 2014. (doi:10.3109/15513815.2014.898721

Abstract

Clinical presentation and histopathology of autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) overlap syndrome (OS) are similar, but their management is different. We conducted a pediatric retrospective cross-sectional study of 34 patients with AIH and PSC. AIH had female predominance (74%) and was lower in PSC (45%). 

Read More by clicking here: http://informahealthcare.com/doi/abs/10.3109/15513815.2014.898721
Posted online on April 22, 2014. (doi:10.3109/15513815.2014.898721)

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    Research

    Every effort is taken to ensure the research presented is from reputable sources. 

    In order to ensure that copyright is not breached, only a small portion of the abstract is provided here. Clicking on the title will take you to the original journal, or site, where the abstract has been published. Most times only an abstract of an article is available as subscriptions are usually required. Occasionally a full text is made freely available.

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    Page created 09.03.2014
    Updated: 09.04.2014
Disclaimer:  The information presented on this website is intended for information and educational purposes only, and is not intended to be a substitute for medical advice or information in any way. The information is not written by a medical practitioner, and as such it should never be used for diagnostic, treatment or management purposes. If you have questions regarding your medical needs, always seek the advice of your doctor, specialist or other appropriate and qualified health care professional.
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