Ulrich Beuers, Michael Trauner, Peter Jansen, Raoul Poupon
Summary:
Cholestasis is an impairment of bile formation/flow at the level of the hepatocyte and/or cholangiocyte. The first, and for the moment, most established medical treatment is the natural bile acid (BA) ursodeoxycholic acid (UDCA). This secretagogue improves, e.g. in intrahepatic cholestasis of pregnancy or early stage primary biliary cirrhosis, impaired hepatocellular and cholangiocellular bile formation mainly by complex post-transcriptional mechanisms. The limited efficacy of UDCA in various cholestatic conditions urges for development of novel therapeutic approaches. ... Please click here to read the full article and/or download the article as a PDF.
Journal of Herpetology, April 2015, Volume 62, Issue 1, Supplement, pp S25-37
DOI: http://dx.doi.org/10.1016/j.jhep.2015.02.023