Scientific Research
This page is in a'blog' format with the latest scientific PSC research identified by Google Scholar, Readbyqmx.com and other sources added regularly.

Systemic therapy for cholangiocarcinoma

Saeed Sadeghi and Richard S. Finn. Clinical Liver Disease, 2014, Special Issue: Autoimmune Liver Disease, Part 4, Volume 3, Issue 4, pages 86–89

Abstract

Cholangiocarcinoma (CCA) is an increasingly common biliary malignancy and accounting for 3% of all gastrointestinal tumors. In the United States, the incidence is 1 to 2 cases per 100,000 population and is uncommon compared with other cancer types. While the incidence of intrahepatic CCAs has been rising in industrialized countries, the incidence of extrahepatic CCA is declining worldwide.1 CCA continues to have a high mortality, with a 5-year survival rate of 10%.[2] In the Western world, the most commonly associated risk factor for CCA is primary sclerosing cholangitis, with an annual risk of 0.5%-1.5%  . . . Please click here to read the full text of this article

Malignancy in primary sclerosing cholangitis: Bile duct, liver, and colon

Roger W. Chapman. Clinical Liver Disease Special Issue: Autoimmune Liver Disease, Part 4, 2014, Volume 3, Issue 4,  pages 83–85,

Abstract

As discussed in companion articles in CLD, the clinical course of large duct primary sclerosing cholangitis (PSC) is highly variable and unpredictable.[1, 2] Although the median survival from presentation to death or liver transplantation in symptomatic patients is approximately 10-12 years, 75% of asymptomatic patients will survive 15 years or more. A recent Dutch study has shown an overall median survival of 22 years in PSC patients.[3] . . . Please click here for the full article

An interview with the author and a video presentation of this article is available by clicking here.

Endoscopic management of primary sclerosing cholangiti

Ryan Law D.O. and Todd H. Baron M.D., Clinical Liver Disease: Special Issue: Autoimmune Liver Disease, Part 4, Volume 3, Issue 4, pages 79–82, April 2014

Abstract

Primary sclerosing cholangitis (PSC) is a progressive, chronic fibroinflammatory disorder involving the intra- and extrahepatic biliary tree that can lead to cirrhosis and liver failure in a subset of patients. Additionally, progression of PSC can lead to life-threatening episodes of ascending cholangitis and the development of cholangiocarcinoma (CCA). Herein we describe the endoscopic evaluation and therapeutic management of PSC and CCA . . . Please click here to read the full article

Update on inflammatory bowel disease in patients with primary sclerosing cholangitis

Christos Tsaitas, Anysia Semertzidou and Emmanouil Sinakos. World J Hepatol. 2014 April 27; 6(4): 1780-187. Published online 2014 April 27. doi: 10.4254/wjh.v6.i4.178.

Abstract

Patients with primary sclerosing cholangitis (PSC) complicated by inflammatory bowel disease (IBD) represent a distinct subset of patients with unique characteristics, which have serious clinical implications. The aim of this literature review was to shed light to the obscure clinical and molecular aspects of the two diseases combined utilizing current data available and putting issues of diagnosis and treatment into perspective. The prevalence of IBD, mainly ulcerative colitis in PSC patients is estimated to be 21%-80%, dependent on screening programs and nationality . . .  Please click here to read further

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation

Bjarte Fosby, Sigrid Næss, Johannes R Hov, James Traherne, Kirsten M Boberg, John Trowsdale, Aksel Foss, Pål-Dag Line, Andre Franke, Espen Melum, Helge Scott and Tom H Karlsen. World J Gastroenterol. 2014 April 14; 20(14): 3986-4000. Published online 2014 April 14. doi: 10.3748/wjg.v20.i14.3986.

Abstract

Aim: To investigate influence of human leukocyte antigen (HLA) and killer immunoglobuline-like receptor (KIR) genotypes on risks of acute rejection (AR) after liver transplantation (LTX).

Methods: In this retrospective study we included 143 adult donor-recipient pairs with a minimum of 6 mo follow-up after LTX for whom DNA was available from both donor and recipients. Clinical data, all early complications including episodes and severity of AR and graft/patient survival were registered. The diagnosis of AR was based on clinical, biochemical and histological criteria. All suspected episodes of AR were biopsy confirmed . . .  Please click here to read further

Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis 

James H. Tabibian, Felicity Enders, Mohamad H. Imam, Gururaj Kolar,  Keith D. Lindor, Jayant A. Talwalkar.
Annals of Hepatology,  2014, May-June, Vol. 13 No. 3, 2014: 384-389

Abstract

Introduction: Primary sclerosing cholangitis (PSC) is an idiopathic hepatobiliary disorder associated with an increased risk for cholangiocarcinoma (CCA) and a median survival time of 12 years. Reliable predictors of CCA and other major adverse events in PSC are currently lacking. Recently, serum IgE was found to be as- sociated with CCA in a Japanese cohort of PSC patients. Our aim in this study was to determine whether IgE levels predict time to CCA, liver transplantation, or death in a Western (USA-based) cohort of PSC pa- tints. 

Material and methods: Thirty-eight patients with PSC and IgE levels were identified and categorized into low or high IgE groups based on the sample median. Groups were compared with respect to clinical characteristics and adverse endpoint-free survival . . . Please click here to be taken to the full text article

Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children and Adolescents.

Claudia Patricia Rojas, Rajasekhar Bodicharla,  German Campuzano-Zuluaga, Lina Hernandez, and Maria Matilde Rodriguez Posted online on April 22, 2014. (doi:10.3109/15513815.2014.898721

Abstract

Clinical presentation and histopathology of autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) overlap syndrome (OS) are similar, but their management is different. We conducted a pediatric retrospective cross-sectional study of 34 patients with AIH and PSC. AIH had female predominance (74%) and was lower in PSC (45%). 

Read More by clicking here: http://informahealthcare.com/doi/abs/10.3109/15513815.2014.898721
Posted online on April 22, 2014. (doi:10.3109/15513815.2014.898721)