Elisabeth M G de Vries, Joanne Verheij, Stefan G Hubscher, Mariska M G Leeflang, Kirsten Boonstra, Ulrich Beuers, Cyriel Y Ponsioen
This study looks at three staging systems that may be useful to act as surrogate endpoints in PSC.
BACKGROUND & AIMS:
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. At present, there is no appropriate histologic scoring system available for PSC, evaluating both degree of necroinflammatory activity (grade) and fibrosis (stage). The aim of this study was to assess if three scoring systems, commonly used in different liver diseases could be applied for grading and/or staging of PSC.
METHODS:
Sixty-four PSC patients from a Dutch cohort, who underwent diagnostic liver biopsy, were included. Staging was scored using Ishak, Nakanuma, and Ludwig systems. Grading was scored using Ishak and Nakanuma systems. ... Please click here to read the remainder of the abstract.
Journal of Hepatology 2015, 63 (5): 1212-9
This study looks at three staging systems that may be useful to act as surrogate endpoints in PSC.
BACKGROUND & AIMS:
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. At present, there is no appropriate histologic scoring system available for PSC, evaluating both degree of necroinflammatory activity (grade) and fibrosis (stage). The aim of this study was to assess if three scoring systems, commonly used in different liver diseases could be applied for grading and/or staging of PSC.
METHODS:
Sixty-four PSC patients from a Dutch cohort, who underwent diagnostic liver biopsy, were included. Staging was scored using Ishak, Nakanuma, and Ludwig systems. Grading was scored using Ishak and Nakanuma systems. ... Please click here to read the remainder of the abstract.
Journal of Hepatology 2015, 63 (5): 1212-9
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