A Review of the Challenges Associated with the Diagnosis and Therapy of Primary Sclerosing Cholangitis

​Primary sclerosing cholangitis (PSC) is a chronic and progressive cholestatic liver disease that often leads to the development of cirrhosis. Complications of PSC include pruritus, fatigue, vitamin deficiencies, metabolic bone disease, dominant biliary strictures, gallstones, and hepatobiliary malignancies, most commonly cholangiocarcinoma (CCA). Despite the presumed autoimmune etiology of PSC, a clear benefit from immunosuppressive agents has not yet been established, and their use is limited by their side effects. Endoscopy is required in evaluation of biliary strictures in PSC to rule out the possibility of CCA ... The full text of this article is available by clicking here. 
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Mohammed Saadi, Christine Yu, and  Mohamed O. Othman
J Clin Transl Hepatol. 2014 Mar; 2(1): 45–52. 
Published online 2014 Mar 15. doi:  10.14218/JCTH.2013.00021